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In accordance with section 1833(t)(2)(B) of the Act, subject to certain exceptions, items and services within an APC group cannot be considered comparable with respect to the use of resources if the highest median cost (or mean cost, if elected by the Secretary) for an item or service in the APC group is more than 2 times greater than the lowest median cost (or mean cost, if elected by the Secretary) for an item or service within the same APC group (referred to as the 2 times rule)

Combined with semaglutide (CagriSema), it demonstrated 20.4% weight loss in the Phase 3 REDEFINE 1 trial, approaching the efficacy of bariatric surgery

Another consideration is the presence of the enzyme diamine oxidase (DAO)

2009 Feb-Apr;30(1-2):1-12

That calculator is for reconstitution math only and is distinct from CagriSema, which combines cagrilintide with semaglutide