10.1038/s41467-018-03941-2 26 KaelbererM
GPx is primarily involved in redox homeostasis as well as several other important functions 59 , whereas, telomerase is involved in telomere maintenance and a wide variety of extratelomeric functions, including suspected neuroprotective and antidepressant-like effects
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Thus, integration of both hormones into a single molecule may not only maximize the metabolic efficacy of the individual signals, but allow also specific delivery of estrogen into GLP1 receptor-expressing cells, avoiding potential undesired effects of estrogen on reproductive tissues, as shown also in our studies
To correct for multiple comparisons across physiological and subjective measures, we applied a familywise false discovery rate of 0.05 [50]
