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Accessed July 18, 2023

Time The more treatment is delayed, the more the brain is damaged

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mAChRs are G-protein coupled receptors (metabotropic), of which there are five subtypes, M1-M5 [163, 178]

While the unidirectional laminar flow is detected by mechanoreceptors on ECs (e.g., cilia, glycocalyx, membrane receptors, and ion channels) and sustains elevated intracellular calcium and NO production via nuclear factor-E2-related factor 2 (Nrf2), this effect is lost in flow stasis [67, 68]