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[3] Cell Line:insulin + palmitic acid-induced insulin-resistant HepG2 cells, primary mouse hepatocytes, C2C12 mouse skeletal muscle myotubes Concentration:0, 20, 40, 80 M Incubation Time:24 h (following 24 h insulin + PA pre-treatment) Result:Significantly increased phosphorylation of p-IGF-1R (Tyr1135), p-IRS1 (Tyr612), p-PI3K, and p-Akt (Ser473) in a dose-dependent manner relative to insulin + PA-only treated cells across all three cell types, with significant increases observed at 20, 40, and 80 M
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The effort expands an existing program under the Evernorth unit called EncircleRx, which targets patients with diabetes, obesity and cardiovascular disease
Jessica Reilly, medical director of the Strong4Life pediatric obesity clinic at Childrens Healthcare of Atlanta