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NICE guidance provides clear recommendations for GLP-1 use, which focus exclusively on glycaemic control in type 2 diabetes (NG28) and weight management in obesity (TA875 for semaglutide, TA664 for liraglutide)

This is because in the first three months of weight loss with GLP-1, supportive measures such as resistance training and sufficient protein intake can mitigate some of the sagging, hollowing and wrinkling and skin quality changes

Mechanistic investigations highlight that GLP-1 RAs have not just weight loss, but also anti-inflammatory and metabolic properties, suggesting their efficacy against several chronic conditions

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Since then, shortages have ended, and the FDA says [archived link] the non-approved compounded versions can no longer be made and sold