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On the dealmaking front, J&J acquired Halda Therapeutics in a $3.05 billion deal that includes Haldas Riptac cell-death platform and its lead candidate HLD-0915, an oral small-molecule therapy targeting metastatic castration-resistant prostate cancer (mCRPC), along with additional RIPTAC-based programs for other solid tumors

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Because a definitive histologic distinction between carcinoma in situ and bowenoid papulosis is not possible, clinical correlation is necessary to confirm this diagnosis