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IARC Scientific Publications (148): 231249

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compared the affinities of AM404 for brain TRPV1 and CB1 receptors and reported that the concentration of AM404 required to activate TRPV1 receptors is much lower than that required for CB1 receptors ( Other Mechanisms Another possible reason for the analgesic action of acetaminophen could be the action of endogenous neurotransmitter systems including opioid and serotonergic systems