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Policy decisions on the reimbursement of tirzepatide in individual countries should be based on health technology assessments integrating long-term efficacy and safety clinical data with country-specific cost-utility analyses comparing tirzepatide with other glucose-lowering medications used in clinical practice

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3.4 GSAAT interacts with TRX isoforms and with NTRC We used different methodological approaches to confirm the interactions of GSAAT with TRXs and NTRC

pQCT data possibly suggested the cortical BMC boost could be due to a larger bone cross-section, while the cortical volumetric BMD (bone volume density) might have stayed stable