un IMC de 27 o superior y al menos una condicin mdica relacionada con el peso, como prediabetes o diabetes tipo 2, hipertensin arterial, dislipidemia, sndrome de apnea obstructiva del sueo o enfermedad cardiovascular
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Front Med (Lausanne) 7:563020 Timsit J, Riou B, Bertherat J, Wisnewsky C, Kato NS, Weisberg AS, Lubetzki J, Lecarpentier Y, Winegrad S, Mercadier JJ (1990) Effects of chronic growth hormone hypersecretion on intrinsic contractility, energetics, isomyosin pattern, and myosin adenosine triphosphatase activity of rat left ventricle
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revealed that the inhibition of PTEN via the activation of the PI3K/AKT pathway attenuated endoplasmic reticulum stress and apoptosis in APP/PS1 transgenic AD model mice [16]
