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J Drug Deliv Ther 8

A., Hhmer, A

These signs may warrant a dose adjustment, temporary pause, or evaluation for a bowel obstruction, though obstruction is rare

One possible explanation is that tirzepatide activates GIP receptors on GABAergic neurons in the nucleus tractus solitarius and area postrema, which are involved in anti-emetic mechanisms, thereby reducing the occurrence of nausea and vomiting [85, 86]