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627 Traditionally, MDD was attributed to neurotransmitter alterations or brain-derived neurotrophic factor disorders

Patients should be told this directly, and it should appear in the consent conversation

Conversely, MI modulates insulin effects and enhances aromatase and FSH receptor expression, contributing to improved ovarian hormone synthesis (142)

These typically resolve on their own or by temporarily reducing the dose

Institutional Review Board Statement The study was conducted according to the guidelines of the Declaration of Helsinki, and approved by the Ethics Committee of School of Medicine, University of Zagreb (protocol code 380-59-10106-17-1001290 and date of approval 02 November 2020)