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In conclusion, there is a strong association between GPX4 and obesity, and GPX4-centered ferroptosis may be the key link between GPX4 and obesity FSP1 Ferroptosis-suppressor-protein 1 (FSP1) is a recently discovered non-GPX4-dependent ferroptosis inhibitory factor, which exhibits a different pathway of action from GPX4 in the process of ferroptosis inhibition, mainly regulated by the NAD (P)H/FSP1/CoQ10 system (45) ( Figure 1C )