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Along with alcohol/drug addiction, individuals might develop addictions toward natural rewards, such as sex and palatable foods

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Through histone modification, curcumin downregulates histone acetyltransferases (p300/CBP) and histone deacetylases (HDAC1, HDAC3), restoring normal chromatin architecture and transcriptional activity of growth-regulating genes (Reuter et al., 2011)